高平

一、个人简介

高平，博士，教授，博士生导师。2012年7月毕业于西北农林科技大学，获得硕士学位。2016年12月毕业于芬兰奥卢大学生物化学与分子医学学院，获得博士学位。2017年1月至2018年8月在芬兰奥卢大学从事博士后研究。2018年10月-至今入职5822yh银河国际。研究成果以第一作者或通讯作者发表在Oncogene，Cell，Nature Genetics，Clinical Cancer Research和Int J Mol Sci等杂志上，此外，申请人还在Nature Genetics, Nature Communication, Cancer Research等杂志上以共同作者发表研究性论文九篇。

二、主要研究领域及兴趣

1.前列腺癌的发病机制研究。

2.前列腺癌的临床药物筛选和风险预测。

三、承担的科研项目

1.主持国家自然科学基金面上项目，ITGA1在前列腺癌发生发展中的作用及机制研究，2020.1-2023.12，81972417，在研；

2.主持陕西省自然科学基础研究计划一般项目（面上），前列腺癌中E2F1与TEAD1调控关系的研究，2020.1-2021.12，2020JM-292，已结题；

3.参与陕西省自然科学基础研究计划一般项目（青年），GATA2与EEFSEC相互作用在前列腺癌中的作用机制研究，2020.01-2021.12，2020JQ-430，已结题。

四、代表性论文 (#co-first author; *corresponding author)

1.Gao P#*, Hao JL, Xie QW, Han GQ, Xu BB, Hu H, Sa N, Du XW, Tang HL, Yan J, Dong XM*. PELO facilitates PLK1-induced the ubiquitination and degradation of Smad4 and promotes the progression of prostate cancer.Oncogene, 2022 May; 41(21):2945-2957.

2. Dong XM#, Zhang Q#, Hao JL#, Xie QW, Xu BB, Zhang P, Qilai Huang, Yang TL, Wei GH#, Na R# andGao P*. Large multicohort study reveals a prostate cancer susceptibility allele at 5p15 regulating TERT via androgen signaling-orchestrated chromatin binding of E2F1 and MYC.Frontiers in Oncology, 2021 Nov 10; 11:754206.

3.Gao P#*, Dong XM#, Wang Y#, Wei GH*. Optimized CRISPR/Cas9- mediated single nucleotide mutation in adherent cancer cell lines,Star Protocols, 2021 Mar 31; 2(2):100419.

4.Gao P#, Xia JH#, Sipeky C, Dong XM, Zhang Q, Yang Y, Zhang P, Cruz SP，Zhang K, Zhu J, Lee HM, Suleman S, Giannareas N, Liu S, The PRACTICAL consortium, Tammela T，Auvinen A，Wang XY, Huang QL, Wang L, Manninen A, Vaarala MH, Wang L, Schleutker J, Wei GH*. Biology and clinical implications of the 19q13 aggressive prostate cancer susceptibility locus.Cell, 2018 Jul; 174(3):576-589.

5. Sipekya C#,Gao P#, Zhang Q, Wang L, Ettala O, Talala MK, Tammela LJT, Auvinen A, the PRACTICAL consortium, Wiklund F, Wei GH*, Schleutker J#.Synergistic interaction of HOXB13 and CIP2A predispose to aggressive prostate cancer.Clinical Cancer Research, Dec 15; 24(24):6265-6276.

6. Whitington T#*,Gao P#, Song W, Ross-Adams H, Lamb AD, Yang Y, Svezia I, Klevebring D, Mills IG, Karlsson R, Halim S, Dunning MJ, Egevad L, Warren AY, Neal DE, Grönberg H, Lindberg J, Wei GH, Wiklund F*. Gene regulatory mechanisms underpinning prostate cancer susceptibility.Nature Genetics, 2016 Apr; 48(4): 387-397.

7.Gao P & Wei GH. Genomic Insight into the Role of lncRNA in Cancer Susceptibility.Int J Mol Sci, 2017 Jun 9; 18(6) :1239.

8. Huang Q#, Whitington T#,Gao P, Lindberg JF, Yang Y, Sun J, Väisänen MR, Szulkin R, Annala M, Yan J, Egevad LA, Zhang K, Lin R, Jolma A, Nykter M, Manninen A, Wiklund F, Vaarala MH, Visakorpi T, Xu J, Taipale J*, Wei GH*. A prostate cancer susceptibility allele at 6q22 increases RFX6 expression by modulating HOXB13 chromatin binding.Nat Genetics, 2014 Feb; 46(2):126-135.

9. Zhang P#, Xia JH#, Zhu J,Gao P, Tian YJ, Du M, Guo Y, Suleman S, Zhang Q, Kohli M, Tillmans L, Thibodeau S, French A, Cerhan J, Wang LD, Wei GH，Wang L*. High-throughput screening of prostate cancer risk loci by single nucleotide polymorphisms sequencing.Nature Communication, 2018 May 22; 9(1):2022.

10. Zhang B , Chen MY, Sheng YJ, Zhuo XB,Gao P, Zhou FS, Liang B, Zu J, Zhang Q, Suleman S, Xu YH, Xu MG, Xu JK, Liu CC, Giannareas N, Xia JH, Zhao Y, Huang ZL, Yang Z, Cheng H, Li N, Hong YY, Li W, Zhang MJ, Yu KD, Li G, Sun MH, Chen ZD, Wei GH, Shao ZM. A large-scale, exome-wide association study of Han Chinese women identifies three novel loci predisposing to breast cancer.Cancer Res, 2018 Jun 1; 78(11):3087-3097.

11. Chen Y, Zhang Q, Wang Q, Li J, Sipeky C, Xia J,Gao P, Hu Y, Zhang H, Yang X, Chen H, Jiang Y, Yang Y, Yao Z, Chen Y, Gao Y, Tan A, Liao M, Schleutker J, Xu J, Sun Y, Wei GH & Mo Z. Genetic association analysis of the RTK/ERK pathway with aggressive prostate cancer highlights the potential role of CCND2 in disease progression.Sci Rep, 2017 Jul 3;7(1):4538.

12. Zhang K, Myllym ki SM,Gao P, Devarajan R, Kyt?l? V, Nykter M, Wei GH, Manninen A. Oncogenic K-Ras upregulates ITGA6-expression via FOSL1 to induce anoikis resistance and synergizes with αV-class integrins to promote EMT.Oncogene, 2017 Oct 12; 36(41):5681-5694.

13. Taipale M, Jakkula E, K?m?r?inen OP,Gao P, Skarp S, Barral S, Kiviranta I, Kr?ger H, Ott J, Wei GH, Ala-Kokko L, M?nnikk? M. Targeted re-sequencing of linkage region on 2q21 identifies a novel functional variant for hip and knee osteoarthritis. Osteoarthritis Cartilage, 24 (2016) 655-663. doi: 10.1016/j.joca.

14. Du M, Tillmans L, Gao J,Gao P, Yuan T, Dittmar RL, Song W, Yang Y, Sahr N, Wang T, Wei GH, Thibodeau SN, Wang L. Chromatin interactions and candidate genes at ten prostate cancer risk loci.Sci Rep, 2016 Mar 16; 6:23202.

15. Heinonen H, Lepikhova T, Sahu B, Pehkonen H, Pihlajamaa P, Louhimo R,Gao P, Wei GH, Hautaniemi S, J?nne OA, Monni O. Identification of several potential chromatin binding sites of HOXB7 and its downstream target genes in breast cancer.Int J Cancer, 2015 Nov 15; 137(10):2374-83.

16. Munne PM, Gu Y, Tumiati M,Gao P, Koopal S, Uusivirta S, Sawicki J, Wei GH, Kuznetsov SG. TP53 supports basal-like differentiation of mammary epithelial cells by preventing translocation of deltaNp63 into nucleoli.Sci Rep, 2014 Apr 11; 4:4663.

五、获奖情况

1．最佳博士论文奖，2016，奥卢大学医学院与生物化学与分子医学学院；

2．年度发现奖，2016，奥卢大学生物中心；

3．年度发现奖，2014，奥卢大学生物中心。